This paper analyses six strategies for managing the MSW generated in Asturias (Spain) in terms of their environmental impacts applying the Life Cycle Analysis methodology. To this end, the effect of these strategies on Human Health, Ecosystem Quality, Global Warming and Resource Depletion is studied. The analysed management options include direct landfill with recovery of biogas (S-0), direct incineration with energy recovery (S-1), biomethanization of the source-separated organic fraction with direct incineration of the mixed fraction (S-2), biomethanization of the source-separated organic fraction, sorting of the mixed fraction and incineration of the rejected fraction (S-3), biomethanization of the source-separated organic fraction, sorting of the mixed fraction and incineration of the rejected fraction following aerobic stabilization of the organic fraction (S-4) and biomethanization of the source-separated organic fraction, sorting of the mixed fraction and landfill of the rejected following aerobic stabilization of the organic fraction (S-5). The Consortium for Waste Management (COGERSA) provide data regarding on transport and collection of waste and consumption of energy, water, oil and reagents at each processes. The results obtained suggest that Scenario S-3 has the least impact on the analysed damage categories while the scenarios including landfilling produces the greatest impact in all the categories analysed. Regarding involved processes in studied scenarios, the transport produces a significant impact in the environment, biomethanization contributes to reducing the impact in all the damage categories and incineration adversely affects the categories of Human Health and Climate Change, but helps to reduce damage in the Resources category. •Six waste management scenarios were assessed by LCA methodology.•Four damage categories were considered, according to the Impact 2002+ method.•Waste landfilling is the option with greater environmental impacts.•Sorting and biomethanization processes provide savings in the studied categories.•Incineration helps to reduce damage in the Resources Depletion category.