How Ca2+-ATPase pumps ions across the sarcoplasmic reticulum membrane

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How Ca2+-ATPase pumps ions across the sarcoplasmic reticulum membrane

Toyoshima, Chikashi

Biochimica et biophysica acta 1793, Issue: 6

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Ca2+-ATPase of muscle sarcoplasmic reticulum is an ATP-powered Ca2+-pump that establishes a >10,000 fold concentration gradient across the membrane. Its crystal structures have been determined for 9 different states that cover nearly the entire reaction cycle. Presented here is a brief structural account of the ion pumping process, with emphasis on why the structure has to be so.

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Toyoshima, Chikashi

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