The bioeconomy is positioned as a sustainable pathway to address the climate crisis and decrease the consumption of fossil resources. Life cycle methodologies are recognised as useful tools for assessing sustainability issues of production and consumption patterns. Nevertheless, the Social Life Cycle Assessment (S-LCA) methodology is less explored despite its potential, although it is true that social sustainability assessment in promoting bioeconomy strategies requires more attention. This study describes the state of the art of the S-LCA methodology under the bioeconomy framework, critically analysing the main procedural and practical issues of its implementation, and the eventual specificities, as well as providing some of the challenges for future studies. This review highlights methodological weaknesses that require further research, related to the definition of system boundaries and cut-off criteria, the method of impact assessment, and the selection of societal issues and stakeholders, as well as uncertainty, among others. In addition, particularities of the bioeconomy in the life perspective were noted, such as multifunctionality and allocation issues of bio-based products, as well as the strong interest in biofuel production systems. Therefore, more efforts are desirable to address the diversity of challenges towards the progress of the S-LCA method in line with other life cycle approaches (environmental and economic). However, the updated S-LCA Guidelines represent a useful and valuable starting point on the way towards a comprehensive (i.e., diverse social concerns) and standardised social assessment under a life cycle perspective. Display omitted •This study provides a comprehensive review of S-LCA in the bioeconomy framework.•Workers and related social categories are in the focal point of interest.•Biofuels production is the most widely analysed bio-based system.•Diverse methodological frameworks have been proposed to strengthen the S-LCA method.•The main weaknesses and challenges in the application of S-LCA are discussed.