The purpose of this study is the analysis of vulnerability trends, with particular emphasis to the evolution of the seismic behaviour of masonry buildings over the years due to the improvements in construction practices and to the enhancement of building materials over the years, also related to the subsequent enactment of seismic prescriptions. To this aim, residential masonry buildings damaged after the 2009 L'Aquila earthquake are considered, coming from the online platform Da.D.O. ( Database di Danno Osservato , Database of Observed Damage) recently released from the Italian Department of Civil Protection. General features of all the parameters available from the original database are thoroughly analysed, a selection of which is used for vulnerability analysis, namely the period of construction and the design type, the presence of structural interventions, the type of horizontal structure. Vulnerability curves are obtained through an optimization technique, minimizing the deviation between observed and predicted damage. PGA from ShakeMap is used for ground motion characterization. Damage levels defined according to the European Macroseismic Scale are considered, obtained from the observed damage for vertical structures collected during the inspections. Vulnerability curves are firstly obtained as a function of period of construction and horizontal structural types, limited to the irregular layout and bad quality vertical type only, highlighting their clear influence on seismic behaviour. Lastly, the effectiveness of retrofit intervention is evaluated comparing the vulnerability curves for strengthened masonry buildings compared to those not subjected to any retrofit interventions.