Abstract The Cherenkov Telescope Array (CTA) is the next-generation ground-based very-high-energy gamma-ray observatory. By using three types of telescopes CTA can cover a wide energy range (20 GeV–300 TeV) with an order of magnitude higher sensitivity than the current telescopes. The Large-Sized Telescope (LST) is designed to detect 20 GeV–1 TeV gamma rays thanks to the large light collection area, sensitive photosensors, a fast trigger system, and readout electronics. The camera readout system must have a high signal-to-noise ratio and a linear signal sampling with a large dynamic range in order to efficiently detect dim and low-energy atmospheric showers. To meet this requirement we use the Domino Ring Sampler version 4 (DRS4), which also enables ultra-fast sampling with low power consumption. Some of the intrinsic characteristics of DRS4 chips require software corrections. These procedures lower the effect of non-Gaussian noise contribution and improve the timing resolution of the system. In this contribution we discuss the calibration algorithms and the resulting performance.