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Qin, Shiyi; Zhang, Qi; Xu, Yanhua; Ma, Shuo; Wang, Tianyi; Huang, Yuejiao; Ju, Shaoqing
Molecular medicine (Cambridge, Mass.), 07/2022, Volume: 28, Issue: 1Journal Article
Abstract Circular RNAs (circRNAs) have become a research hotspot in recent years with their universality, diversity, stability, conservativeness, and spatiotemporal specificity. N 6 -methyladenosine (m 6 A), the most abundant modification in the eukaryotic cells, is engaged in the pathophysiological processes of various diseases. An increasing amount of evidence has suggested that m 6 A modification is common in circRNAs and is associated with their biological functions. This review summarizes the effects of m 6 A modification on circRNAs and their regulation mechanisms in cancers, providing some suggestions of m 6 A-modified circRNAs in cancer therapy.
