Three-Component Synthesis of Some New Coumarin Derivatives as Anticancer Agents

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Three-Component Synthesis of Some New Coumarin Derivatives as Anticancer Agents

Alshabanah, Latifah A; Al-Mutabagani, Laila A; Gomha, Sobhi M; Ahmed, Hoda A

Frontiers in chemistry, 01/2022, Volume: 9

Journal Article

A three-component reaction for the synthesis of novel 3-heteroaryl-coumarin utilizing acetylcoumarin synthon under ultrasonic irradiation was developed using chitosan-grafted poly(vinylpyridine) as an eco-friendly catalyst. The process is a simple, facile, efficient procedure for the preparation of compounds displaying a thiazole ring linked to coumarin moiety. Moreover, all the products were evaluated for their anticancer activities against HEPG2-1. The results revealed that three new compounds showed promising anticancer activities.

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Alshabanah, Latifah A | Al-Mutabagani, Laila A | Gomha, Sobhi M | Ahmed, Hoda A

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