LDL receptor in alphavirus entry: structural analysis and implications for antiviral therapy

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LDL receptor in alphavirus entry: structural analysis and implications for antiviral therapy

Wang, Ningning; Merits, Andres; Veit, Michael; Lello, Laura Sandra; Kong, Shuhan; Jiao, Houqi; Chen, Jie; Wang, Yu; Dobrikov, Georgi; Rey, Félix A; Su, Shuo

Nature communications, 06/2024, Volume: 15, Issue: 1

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Abstract Various low-density lipoprotein receptors (LPRs) have been identified as entry factors for alphaviruses, and structures of the corresponding virion-receptor complexes have been determined. Here, we analyze the similarities and differences in the receptor binding modes of multiple alphaviruses to understand their ability to infect a wide range of hosts. We further discuss the challenges associated with the development of broad-spectrum treatment strategies against a diverse range of alphaviruses.

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