Tuberculosis is one of the most contagious and lethal illnesses in the world, according to the World Health Organization. Tuberculosis had the leading mortality rate as a result of a single infection, ranking above HIV/AIDS. Early detection is an essential factor in patient treatment and can improve the survival rate. Detection methods should have high mobility, high accuracy, fast detection, and low losses. This work presents a novel biomedical photonic crystal fiber sensor, which can accurately detect and distinguish between the different types of tuberculosis bacteria. The designed sensor detects these types with high relative sensitivity and negligible losses compared to other photonic crystal fiber-based biomedical sensors. The proposed sensor exhibits a relative sensitivity of 90.6%, an effective area of 4.342×10 −8 m 2 , with a negligible confinement loss of 3.13×10 −9 cm −1 , a remarkably low effective material loss of 0.0132cm −1 , and a numerical aperture of 0.3462. The proposed sensor is capable of operating in the terahertz regimes over a wide range (1 THz–2.4THz). An abbreviated review of non-optical detection techniques is also presented. An in-depth comparison between this work and recent related photonic crystal fiber-based literature is drawn to validate the efficacy and authenticity of the proposed design.