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Fribourgh, Jennifer L.; Nguyen, Henry C.; Matreyek, Kenneth A.; Alvarez, Frances Joan D.; Summers, Brady J.; Dewdney, Tamaria G.; Aiken, Christopher; Zhang, Peijun; Engelman, Alan; Xiong, Yong
Cell host & microbe, 11/2014, Volume: 16, Issue: 5Journal Article
The myxovirus resistance (Mx) proteins are interferon-induced dynamin GTPases that can inhibit a variety of viruses. Recently, MxB, but not MxA, was shown to restrict HIV-1 by an unknown mechanism that likely occurs in close proximity to the host cell nucleus and involves the viral capsid. Here, we present the crystal structure of MxB and reveal determinants involved in HIV-1 restriction. MxB adopts an extended antiparallel dimer and dimerization, but not higher-ordered oligomerization, is critical for restriction. Although MxB is structurally similar to MxA, the orientation of individual domains differs between MxA and MxB, and their antiviral functions rely on separate determinants, indicating distinct mechanisms for virus inhibition. Additionally, MxB directly binds the HIV-1 capsid, and this interaction depends on dimerization and the N terminus of MxB as well as the assembled capsid lattice. These insights establish a framework for understanding the mechanism by which MxB restricts HIV-1. Display omitted •MxB forms an antiparallel dimer that is important for HIV-1 restriction•MxB interacts directly with HIV-1 capsid assemblies•MxB dimerization is important for restriction and its interaction with HIV-1 capsid•Higher-order MxB oligomerization is not essential for restriction or capsid binding The MxB restriction factor has been shown to inhibit HIV-1 through an unknown mechanism. Fribourgh et al. present the crystal structure of the restriction factor MxB and demonstrate a direct interaction between MxB and HIV-1 capsid that requires the assembled capsid lattice. This study helps delineate the mechanism of HIV-1 restriction by MxB.
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