Quercetin attenuates neuronal death against aluminum-induced neurodegeneration in the rat hippocampus

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Quercetin attenuates neuronal death against aluminum-induced neurodegeneration in the rat hippocampus

Sharma, D.R; Wani, W.Y; Sunkaria, A; Kandimalla, R.J; Sharma, R.K; Verma, D; Bal, A; Gill, K.D

Neuroscience, 06/2016, Volume: 324

Journal Article

Highlights • Quercetin decreases ROS production and increases MnSOD activity. • It also prevents aluminum-induced neuronal apoptosis and reduces DNA fragmentation. • It also attenuates aluminum-induced mitochondrial swelling, loss of cristae and chromatin condensation. • Finally, it acts as an effective antioxidant in vivo against aluminum-induced neurotoxicity.

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