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Zhang, Yali V.; Ni, Jinfei; Montell, Craig
Science (American Association for the Advancement of Science), 06/2013, Volume: 340, Issue: 6138Journal Article
Below a certain level, table salt (NaCl) is beneficial for animals , whereas excessive salt is harmful. However, it remains unclear how low-and high-salt taste perceptions are differentially encoded. We identified a salt-taste coding mechanism in Drosophila melanogaster. Flies use distinct types of gustatory receptor neurons (GRNs) to respond to different concentrations of salt. We demonstrated that a member of the newly discovered ionotropic glutamate receptor (IR) family, IR76b, functioned in the detection of low salt and was a Na⁺ channel. The loss of IR76b selectively impaired the attractive pathway, leaving salt-aversive GRNs unaffected. Consequently, low salt became aversive. Our work demonstrated that the opposing behavioral responses to low and high salt were determined largely by an elegant bimodal switch system operating in GRNs.
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