Negative Control of RpoS Synthesis by the sRNA ReaL in Pseudomonas aeruginosa

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Negative Control of RpoS Synthesis by the sRNA ReaL in Pseudomonas aeruginosa

Thi Bach Nguyen, Hue; Romero A, David; Amman, Fabian; Sorger-Domenigg, Theresa; Tata, Muralidhar; Sonnleitner, Elisabeth; Bläsi, Udo

Frontiers in microbiology, 10/2018, Volume: 9

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(Pae) is an opportunistic human pathogen, able to resist host defense mechanisms and antibiotic treatment. In Pae, the master regulator of stress responses RpoS (σ ) is involved in the regulation of quorum sensing and several virulence genes. Here, we report that the sRNA ReaL translationally silences mRNA, which results in a decrease of the RpoS levels. Our studies indicated that ReaL base-pairs with the Shine-Dalgarno region of mRNA. These studies are underlined by a highly similar transcription profile of a deletion mutant and a over-expressing strain.

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