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Dzoyem, Jean P.; Melong, Raduis; Tsamo, Armelle T.; Maffo, Timoleon; Kapche, Deccaux G.W.F.; Ngadjui, Bonaventure T.; McGaw, Lyndy J.; Eloff, Jacobus N.
Revista Brasileira de Farmacognosia, 03/2017, Volume: 27, Issue: 2Journal Article
Display omitted Four compounds including beauvericin, parahydroxybenzaldehyde, indole-3-carboxylic acid and quinizarin were isolated from endophytic fungus Epicoccum nigrum and their cytotoxicity, antibacterial and antioxidant activity were evaluated. Beauvericin had remarkable activity against two Gram-negative strains (Bacillus cereus and Salmonella typhimurium) with respective MIC values of 3.12 and 6.25μg/ml. All the compounds had weak cytotoxic effect on both normal and tumor cells. LC50 values ranged from 40.42 to 86.56μg/ml, 31.87 to 86.57μg/ml and 21.59 to 67.27μg/ml on Vero cells, THP-1 and RAW 264.7 respectively. The present study showed that these compounds could be developed for the formulation of antioxidant-rich therapeutic diets and as a therapeutic agent against bacterial infections.
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