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Gaipov, Abduzhappar; Molnar, Miklos Z.; Potukuchi, Praveen K.; Sumida, Keiichi; Canada, Robert B.; Akbilgic, Oguz; Kabulbayev, Kairat; Szabo, Zoltan; Koshy, Santhosh K.G.; Kalantar-Zadeh, Kamyar; Kovesdy, Csaba P.
The Journal of thoracic and cardiovascular surgery, 03/2019, Volume: 157, Issue: 3Journal Article
Coronary artery bypass grafting (CABG) is associated with better survival than percutaneous coronary intervention (PCI) in patients with mild-to-moderate chronic kidney disease (CKD) and end-stage renal disease (ESRD). However, the optimal strategy for coronary artery revascularization in patients with advanced CKD who transition to ESRD is unclear. We examined a contemporary national cohort of 971 US veterans with incident ESRD who underwent first CABG or PCI up to 5 years before dialysis initiation. We examined the association of a history of CABG versus PCI with all-cause mortality following transition to dialysis using Cox proportional hazards models adjusted for time between procedure and dialysis initiation, sociodemographics, comorbidities, and medications. In total, 582 patients underwent CABG and 389 patients underwent PCI. The mean age was 64 ± 8 years, 99% of patients were male, 79% were white, 19% were African American, and 84% had diabetes. The all-cause post-dialysis mortality rates after CABG and PCI were 229 per 1000 patient-years (95% confidence interval CI, 205-256) and 311 per 1000 patient years (95% CI, 272-356), respectively. Compared with PCI, patients who underwent CABG had 34% lower risk of death (multivariable adjusted hazard ratio, 0.66; 95% CI, 0.51-0.86, P = .002) after initiation of dialysis. Results were similar in all subgroups of patients stratified by age, race, type of intervention, presence/absence of myocardial infarction, congestive heart failure, and diabetes. CABG in patients with advanced CKD was associated lower risk of death after initiation of dialysis compared with PCI. In this large nationally representative cohort of US veterans with incident ESRD, pre-ESRD history of coronary artery revascularization with CABG was associated with a 34% lower multivariable adjusted risk of death after initiation of dialysis compared with PCI. CKD, Chronic kidney disease; CABG, coronary artery bypass grafting; PCI, percutaneous coronary intervention. Display omitted
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