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Baztarrika, Itsaso; Salazar-Sánchez, Adrián; Hernaez Crespo, Silvia; López Mirones, José Israel; Canut, Andrés; Alonso, Rodrigo; Martínez-Ballesteros, Ilargi; Martinez-Malaxetxebarria, Irati
Archives of microbiology, 11/2023, Volume: 205, Issue: 12Journal Article
The surge in human arcobacteriosis has increased interest in determining the mechanisms involved in the pathogenesis of Arcobacter butzleri . Here, genomic analyses and in vitro Caco-2 infection, motility, urease and antimicrobial susceptibility testing (AST) assays were used to characterise the virulence and antimicrobial resistance (AMR) determinants of strains HC-1, isolated from a patient with travellers’ diarrhoea, and HC-2, isolated from another with pruritus. AMR determinants conferring resistance to tetracycline ( tetO , present in both genomes) and to ampicillin and amoxicillin–clavulanic acid ( bla3 , present in HC-2) were identified. The same determinants associated with flagellum, chemotaxis, adhesion and invasion were detected in both, but HC-1 lacked eight flagellar genes. The urease cluster was only present in HC-1. Motility and urease tests confirmed the genetic differences between strains, but no genetic marker related to the inability of HC-2 to adhere and invade was identified. This inability could be conditioning the patient’s pathology.
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