Structural Architecture and Functional Evolution of Wnts

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Structural Architecture and Functional Evolution of Wnts

Bazan, J. Fernando; Janda, Claudia Y.; Garcia, K. Christopher

Developmental cell, 08/2012, Volume: 23, Issue: 2

Journal Article

The crystal structure of a Wnt morphogen bound to its Frizzled receptor ectodomain provides insights into the evolutionary provenance of this complex fold and offers an explanation for why Wnts utilize both lipid- and protein-mediated contacts to engage Frizzleds.

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Bazan, J. Fernando | Janda, Claudia Y. | Garcia, K. Christopher

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