Promising Immunomodulatory Effects of Selected Strains of Dairy Propionibacteria as Evidenced In Vitro and In Vivo

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Promising Immunomodulatory Effects of Selected Strains of Dairy Propionibacteria as Evidenced In Vitro and In Vivo

Foligné, Benoît; Deutsch, Stéphanie-Marie; Breton, Jérôme; Cousin, Fabien J; Dewulf, Joëlle; Samson, Michel; Pot, Bruno; Jan, Gwénaël

Applied and Environmental Microbiology, 12/2010, Volume: 76, Issue: 24

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Immunomodulatory properties of 10 dairy propionibacteria, analyzed on human peripheral blood mononuclear cells (PBMCs), revealed a highly strain-dependent induction of anti-inflammatory cytokine interleukin 10 (IL-10). Two selected strains of Propionibacterium freudenreichii showed a protective effect against two models of colitis in mice, suggesting a probiotic potential predicted by immune-based selection criteria for these cheese starter bacteria.

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