TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants

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TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants – past, present and future

Sedger, Lisa M; McDermott, Michael F

Cytokine & growth factor reviews, 08/2014, Volume: 25, Issue: 4

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Highlights • TNF (despite its name) failed clinical trials as an anti-cancer agent. • TNF is a critical component of cell death and inflammation. • Therapeutic blockade of TNF by mAbs and TNFR-fusion proteins ameliorates inflammatory diseases. • Anti-TNF biologics are currently being investigated in neuropathology. • New anti-TNF therapeutics are required to simultaneously permit TNF's role in normal biology and/or selectively block individual TNFR pathways.

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Sedger, Lisa M | McDermott, Michael F

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