A reduction in long-term spatial memory persists after discontinuation of peripubertal GnRH agonist treatment in sheep

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A reduction in long-term spatial memory persists after discontinuation of peripubertal GnRH agonist treatment in sheep

Hough, D; Bellingham, M; Haraldsen, I.R; McLaughlin, M; Robinson, J.E; Solbakk, A.K; Evans, N.P

Psychoneuroendocrinology, 03/2017, Volume: 77

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Highlights • Peripubertal GnRHa impaired long-term spatial memory. • This impairment was not reversed after discontinuing GnRHa-treatment. • Spatial orientation and learning performance remained unaffected following GnRHa withdrawal. • Speed of progression through these spatial tasks was altered after discontinuing GnRHa. • GnRH irreversibly alters these cognitive functions during critical window of development

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