E-resources
-
De Biasi, Sara; Meschiari, Marianna; Gibellini, Lara; Bellinazzi, Caterina; Borella, Rebecca; Fidanza, Lucia; Gozzi, Licia; Iannone, Anna; Lo Tartaro, Domenico; Mattioli, Marco; Paolini, Annamaria; Menozzi, Marianna; Milić, Jovana; Franceschi, Giacomo; Fantini, Riccardo; Tonelli, Roberto; Sita, Marco; Sarti, Mario; Trenti, Tommaso; Brugioni, Lucio; Cicchetti, Luca; Facchinetti, Fabio; Pietrangelo, Antonello; Clini, Enrico; Girardis, Massimo; Guaraldi, Giovanni; Mussini, Cristina; Cossarizza, Andrea
Nature communications, 07/2020, Volume: 11, Issue: 1Journal Article
The immune system of patients infected by SARS-CoV-2 is severely impaired. Detailed investigation of T cells and cytokine production in patients affected by COVID-19 pneumonia are urgently required. Here we show that, compared with healthy controls, COVID-19 patients' T cell compartment displays several alterations involving naïve, central memory, effector memory and terminally differentiated cells, as well as regulatory T cells and PD1 CD57 exhausted T cells. Significant alterations exist also in several lineage-specifying transcription factors and chemokine receptors. Terminally differentiated T cells from patients proliferate less than those from healthy controls, whereas their mitochondria functionality is similar in CD4 T cells from both groups. Patients display significant increases of proinflammatory or anti-inflammatory cytokines, including T helper type-1 and type-2 cytokines, chemokines and galectins; their lymphocytes produce more tumor necrosis factor (TNF), interferon-γ, interleukin (IL)-2 and IL-17, with the last observation implying that blocking IL-17 could provide a novel therapeutic strategy for COVID-19.
Author
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.