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Miliaraki, Marianna; Briassoulis, Panagiotis; Ilia, Stavroula; Polonifi, Aikaterini; Mantzourani, Marina; Briassouli, Efrossini; Vardas, Konstantinos; Nanas, Serafim; Pistiki, Aikaterini; Theodorakopoulou, Maria; Tavladaki, Theonymfi; Spanaki, Anna Maria; Kondili, Eumorfia; Dimitriou, Helen; Tsiodras, Sotirios; Georgopoulos, Dimitrios; Armaganidis, Apostolos; Daikos, George; Briassoulis, George
Scientific reports, 01/2021, Volume: 11, Issue: 1Journal Article
Sepsis is a dysregulated host response to infection related to devastating outcomes. Recently, interest has been shifted towards apoptotic and antiapoptotic pathobiology. Apoptosis is executed through the activation of caspases regulated by a number of antiapoptotic proteins, such as survivin. The survivin and caspases' responses to sepsis have not yet been elucidated. This is a multicenter prospective observational study concerning patients with sepsis (n = 107) compared to patients with traumatic systemic inflammatory response syndrome (SIRS) (n = 75) and to healthy controls (n = 89). The expression of survivin was quantified through real-time quantitative polymerase chain reaction for the different survivin splice variants (wild type-WT, ΔEx3, 2B, 3B) in peripheral blood leukocytes. The apoptotic or antiapoptotic tendency was specified by measuring survivin-WT, caspase-3, and -9 serum protein concentrations through enzyme-linked immunosorbent assay. The survivin-WT, -2B, -ΔΕx3 mRNA, survivin protein, and caspases showed an escalated increase in SIRS and sepsis, whereas survivin-3B was repressed in sepsis (p < 0.05). Survivin correlated with IL-8 and caspase-9 (p < 0.01). For discriminating sepsis, caspase-9 achieved the best receiver operating characteristic curve (AUROC) of 0.95. In predicting mortality, caspase-9 and survivin protein achieved an AUROC of 0.70. In conclusion, specific apoptotic and antiapoptotic pathways might represent attractive targets for future research in sepsis.
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