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Versiani, Alice F; Kaboré, Antoinette; Brossault, Ludovic; Dromenq, Loïc; Dos Santos, Thayza M I L; Milhim, Bruno H G A; Estofolete, Cássia F; Cissé, Assana; Sorgho, Pegdwendé Abel; Senot, Florence; Tessonneau, Marie; Diagbouga, Serge; Nogueira, Mauricio L
Diagnostics (Basel), 03/2023, Volume: 13, Issue: 6Journal Article
Dengue is a serious mosquito-transmitted disease caused by the dengue virus (DENV). Rapid and reliable diagnosis of DENV infection is urgently needed in dengue-endemic regions. We describe here the performance evaluation of the CE-marked VIDAS dengue immunoassays developed for the automated detection of DENV NS1 antigen and anti-DENV IgM and IgG antibodies. A multicenter concordance study was conducted in 1296 patients from dengue-endemic regions in Asia, Latin America, and Africa. VIDAS dengue results were compared to those of competitor enzyme-linked immunosorbent assays (ELISA). The VIDAS dengue assays showed high precision (CV ≤ 10.7%) and limited cross-reactivity (≤15.4%) with other infections. VIDAS DENGUE NS1 Ag showed high positive and negative percent agreement (92.8% PPA and 91.7% NPA) in acute patients within 0-5 days of symptom onset. VIDAS Anti-DENGUE IgM and IgG showed a moderate-to-high concordance with ELISA (74.8% to 90.6%) in post-acute and recovery patients. PPA was further improved in combined VIDAS NS1/IgM (96.4% in 0-5 days acute patients) and IgM/IgG (91.9% in post-acute patients) tests. Altogether, the VIDAS dengue NS1, IgM, and IgG assays performed well, either alone or in combination, and should be suitable for the accurate diagnosis of DENV infection in dengue-endemic regions.
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