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Qiao, Shuo-Wang; Kobayashi, Kanna; Johansen, Finn-Eirik; Sollid, Ludvig M; Andersen, Jan Terje; Milford, Edgar; Roopenian, Derry C; Lencer, Wayne I; Blumberg, Richard S
Proceedings of the National Academy of Sciences - PNAS, 07/2008, Volume: 105, Issue: 27Journal Article
The neonatal Fc receptor for IgG (FcRn) is a distant member of the MHC class I protein family. It binds IgG and albumin in a pH-dependent manner and protects these from catabolism by diverting them from a degradative fate in lysosomes. In addition, FcRn-mediated IgG transport across epithelial barriers is responsible for the transmission of IgG from mother to infant and can also enhance IgG-mediated antigen uptake across mucosal epithelia. We now show a previously undescribed role for FcRn in mediating the presentation of antigens by dendritic cells when antigens are present as a complex with antibody by uniquely directing multimeric immune complexes, but not monomeric IgG, to lysosomes.
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