Atomoxetine reverses locomotor hyperactivity, impaired novel object recognition, and prepulse inhibition impairment in mice lacking pituitary adenylate cyclase-activating polypeptide

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Atomoxetine reverses locomotor hyperactivity, impaired novel object recognition, and prepulse inhibition impairment in mice lacking pituitary adenylate cyclase-activating polypeptide

Shibasaki, Y; Hayata-Takano, A; Hazama, K; Nakazawa, T; Shintani, N; Kasai, A; Nagayasu, K; Hashimoto, R; Tanida, M; Katayama, T; Matsuzaki, S; Yamada, K; Taniike, M; Onaka, Y; Ago, Y; Waschek, J.A; Köves, K; Reglődi, D; Tamas, A; Matsuda, T; Baba, A; Hashimoto, H

Neuroscience, 06/2015, Volume: 297

Journal Article

Highlights • ATX significantly alleviated ADHD-related behavioral abnormalities of PACAP−/− mice. • ATX significantly alleviated impaired prepulse inhibition in PACAP−/− mice. • The ATX-induced increase in extracellular DA and NA levels were higher in PACAP−/− mice compared to wild-type mice. • PACAP−/− mice are an ideal rodent model for the study of ADHD etiology and drug development.

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