E-resources
-
Wei, Shuyan; Chang, Ronald; Holcomb, John B.; Kao, Lillian S.; Holcomb, John B.; Wade, Charles E; Podbielski, Jeanette; Nixon, Joshua; Appana, Savitri N.; Yang, Hui; Gonzalez, Michael O.; Willa Wang, Yao-Wei; Hula, Brittany S.; Espino, Elena; Nguyen, An; Pawelczyk, Nicholas; Sharma, Rishika; Cardenas, Jessica C.; Rahbar, Elaheh; Clark, David; van Belle, Gerald; May, Susanne; Leroux, Brian; Hoyt, David; Sheehan, Kellie; Hubbard, Alan; Arkin, Adam P.; Hess, John R.; Callum, Jeanne; Cotton, Bryan A.; Vincent, Laura; Bai, Yu; McCarthy, James J.; Noland, Amy; Hobbs, Rhonda; Cattin, Lindsay; Warner, Keir J.; Wilson, Angela; Grabinsky, Andreas; Daniel-Johnson, Jennifer A.; Cohen, Mitchell Jay; Nelson, Mary; Redick, Brittney; Conroy, Amanda; Steurer, Marc P.; Maxim, Preston C; Fiebig, Eberhard; Muskat, Peter; Johannigman, Jay A.; Robinson, Bryce RH; Branson, Richard D.; Gomaa, Dina; Barczak, Christopher; Bennett, Suzanne; Carey, Patricia M.; Miller, Christopher N.; Rodriguez, Carolina; Inaba, Kenji; Zhu, Jay G.; Menchine, Michael; Katzberg, Kelly; McKeever, Rodney; Matsushita, Cheryl Y; Stein, Deborah M.; Shaffer, Cynthia K.; Wade, Christine; Kallam, Seeta; Wade, Sarah E.; Fontaine, Magali J.; Hunt, Janice M.; Croce, Martin A.; Wilson, Suzanne; Waddle-Smith, Lynda; Brasel, Karen J.; Walsh, Pamela; Milia, David; Nelson, Allia; Kaslow, Olga; Aufderheide, Tom P.; Gottschall, Jerome L.; Carpenter, Erica; Rokowski, Laurel L.; Denninghoff, Kurt R.; Redford, Daniel T.; Kerby, Jeffrey D.; Bosarge, Patrick L.; Williams, Carolyn R.; Stephens, Shannon W.; Wang, Henry E.; Schreiber, Martin A.; Watters, Jennifer M.; Underwood, Samantha J.; Groat, Tahnee; Rizoli, Sandro; Tien, Homer; Trpcic, Sandy; Sobrian-Couroux, Skeeta; Reis, Marciano; Pérez, Adic; Merkley, Lisa
Journal of the American College of Surgeons, 12/2018, Volume: 227, Issue: 6Journal Article
Endotheliopathy of trauma is characterized by breakdown of the endothelial glycocalyx. Elevated biomarkers of endotheliopathy, such as serum syndecan-1 (Synd-1) ≥ 40 ng/mL, have been associated with increased need for transfusions, complications, and mortality. We hypothesized that severely injured trauma patients who exhibit elevated Synd-1 levels shortly after admission have an increased likelihood of developing sepsis. We analyzed a subset of patients from the Pragmatic, Randomized Optimal Platelet and Plasma Ratios (PROPPR) trial who survived at least 72 hours after hospital admission, and we determined elevated Synd-1 levels (≥ 40 ng/mL) 4 hours after hospital arrival. Sepsis was defined a priori as meeting systemic inflammatory response criteria and having a known or suspected infection. Univariate analysis was performed to identify variables associated with elevated Synd-1 levels and sepsis. Significant variables at a value of p < 0.2 in the univariate analysis were chosen by purposeful selection and analyzed in a mixed effects multivariate logistic regression model to account for the 12 different study sites. We included 512 patients. Of these, 402 (79%) had elevated Synd-1 levels, and 180 (35%) developed sepsis. Median Synd-1 levels at 4 hours after admission were 70 ng/dL (interquartile range IQR 36 to 157 ng/dL) in patients who did not develop sepsis, and 165 ng/dL IQR 67 to 336 ng/dL in those who did (p < 0.001). Adjusting for treatment arm and site, multivariable analyses revealed that elevated Synd-1 status, Injury Severity Score (ISS), and total blood transfused were significantly associated with an increased likelihood of developing sepsis. Elevated Synd-1 levels 4 hours after admission in severely injured adult trauma patients who survived the initial 72 hours after hospital admission are associated with subsequent sepsis.
Author
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.