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Onishi, Akio; Shimura, Yuji; Nakamura, Takahisa; Souri, Masayoshi; Osaki, Tsukasa; Mizutani, Shinsuke; Tsukamoto, Taku; Kobayashi, Tsutomu; Ichinose, Akitada; Kuroda, Junya
Internal Medicine, 08/2023, Volume: 62, Issue: 16Journal Article
Coagulation factor X (FX) deficiency causes severe hemorrhagic symptoms. We herein report a 90-year-old man with hemorrhagic symptoms and prolongation of prothrombin time (PT) and activated partial thromboplastin time (APTT). Cross-mixing tests showed a factor deficiency pattern, but administration of plasma products was not effective. Acquired coagulation factor deficiency was suspected, and immunosuppressive therapy was started. After the intervention, his hemorrhagic symptoms improved. A decrease in FX activity was later confirmed, and anti-FX autoantibody was retrospectively detected by an enzyme-linked immunosorbent assay. Immediate intervention is important for patients suspected of having acquired coagulation factor deficiency.
