Sinteza i farmakološko djelovanje derivata kondenziranih 4-klor-2,2-dialkil kromen-3-karbaldehida

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Sinteza i farmakološko djelovanje derivata kondenziranih 4-klor-2,2-dialkil kromen-3-karbaldehida

IBRAHIM HEGAB, MOHAMED; YOUSEF, NABIL MAHMOUD; NOUR, HANY FATHY; ELLITHEY, MOHEY; SOLIMAN, MAHMOUD

Acta Pharmaceutica, 03/2008, Volume: 58, Issue: 1

Paper

Novi hidrazono- 5a,b, tiosemikarbazono- 6a-c i oksimo kromeni 7a-c sintetizirani su iz odgovarajućeg β-klorkarbaldehida 3 i hidrazina, aromatskog hidrazina, tiosemikarbazida ili hidroksilamin hidroklorida, dok su eterski derivati 8a-h pripremljeni iz pripadajućih aldoksima 7a-c. Novi spojevi ispitani su na protuupalno i ulcerogeno djelovanje, a njihovo djelovanje uspoređeno je s djelovanjem indometacina.

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Author

IBRAHIM HEGAB, MOHAMED | YOUSEF, NABIL MAHMOUD | NOUR, HANY FATHY | ELLITHEY, MOHEY | SOLIMAN, MAHMOUD

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