The paper considers the peculiarities of unique scientific facilities operation (installations of the megascience class), special attention was paid to the activities of the International Center for Neutron Research on the basis of the high-flux research reactor PIK and the prospects for adapting foreign experience to Russian projects. A number of features of organizing access to the results of work on megascience facilities are described. It is shown that there is an access hierarchy structure with the gradual increase of open data impact. The problem of remote access to mega-installations and the organization of the corresponding business processes are considered. The results of the analysis of risks and challenges associated with the organization of work at megascience facilities are described. A number of practical steps have been proposed in order to optimize the use of the outcomes of unique scientific facilities operation. The mechanism of accounting for intellectual property objects is discussed, possible ways of assessing, examining and commercializing the results of scientific research through the cadastre of intellectual property are proposed. It is shown that a number of trends have received additional impetus due to the quarantine regime imposed in connection with the coronavirus infection in 2020.