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Rahbar, Elaheh; Akl, Tony; Cote, Gerard; Moore, James; Zawieja, David
The FASEB journal, April 2014, 2014-04-00, Volume: 28, Issue: S1Journal Article
Objective: To assess lymphatic adaptations to edema, we evaluated lymph transport function in rat mesenteric lymphatics under normal and increased fluid volume (edemagenic) conditions in situ. Methods: Twelve rats were infused with saline (venous infusion, 0.2 ml/min/100g body weight) to induce edema. We intravitally measured mesenteric lymphatic diameter and contraction frequency, as well as immune cell velocity and density before, during and after infusion. Results: A 10‐ and 6‐fold increase in lymph velocity (0.1‐1 mm/s) and flow rate (0.1‐0.6 µL/min), were observed post‐infusion, respectively (p<0.05). There were also increases in contraction frequency and fractional pump flow 1‐minute post‐infusion (p<0.05). Time‐averaged wall shear stress increased 10 times post‐infusion to nearly 1.5 dynes/cm2 (p<0.05). Similarly, maximum shear stress rose from 5 dynes/cm2 to 40 dynes/cm2. Conclusions: Lymphatic vessels adapted to edemagenic stress by increasing lymph transport. Specifically, increases in lymphatic contraction frequency, lymph velocity, and shear stress were statistically significant. Although the changes in lymphatic diameter were not statistically significant, lymph pumping increased post‐infusion. These results suggest that edemagenic conditions stimulate lymph transport via increases in lymphatic contraction frequency, lymph velocity and flow. These changes, consequently, resulted in large increases in wall shear stress, which will activate nitric oxide pathways and modulate lymphatic transport function. Grant Funding Source: NIH Grant No. R01 HL094269, NSF Graduate Research Fellowship
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