Abstract Based on the production and detection procedures of a medical infusion connector, the original detection device was innovatively designed, and an airtightness detection device with automatic loading/unloading function was developed, in an effort to improve the loading/unloading efficiency and airtightness detection efficiency of the infusion connector and complete the automatic detection task at rate of 20-30 ones per min. The basic device composition of this infusion connector was introduced, and the basic structural features and working principles of each device were analyzed. The importance was attached to the calculation methods for key dimensions that influenced the detection quality and material loading, and in this way, while the batch material loading was realized, the difficulties in the airtightness detection and automatic sorting of finished products were solved. The original manual material loading was converted into automatic material loading and the frequency of simultaneous airtightness detection was increased, which reduced the amount of labor used, improved the overall production efficiency and lowered the production cost.