Conducting surgery might be challenging during the pandemic, especially for COVID-19 patients. This is because of the high transmissibility rate of the infection, which might lead to spreading the infection. Moreover, surgery might be associated with further risk over affected patients, a significant contributor to the operated patients' impaired immunity and generalized inflammatory state. Surgery is usually associated with an increased risk of high-stress levels and a generalized inflammatory state flare-up. The present literature review discusses the mortality rates and associated factors for COVID-19 patients during the incubation period. Our findings show that these patients have higher mortality rates as surgery influences the release of high levels of proinflammatory cytokines. Besides, surgery might impair the immune functions leading to progressive deterioration of COVID-19. On the other hand, it has been reported that COVID-19 can also worsen the outcomes and increase the risk of morbidities and mortality among patients undergoing surgery. Different factors have been identified to contribute to this risk, including old age, being male, and the presence of comorbidities. Therefore, avoiding surgery during infection is suggested to reduce the risk of mortality, especially among patients with multiple risk factors. However, it should be noted that this evidence needs further validation.