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  • Getting in: The structural ...
    Kumar, Hirdesh; Tolia, Niraj H

    PLoS pathogens, 09/2019, Volume: 15, Issue: 9
    Journal Article

    CeITOS, cell traversal protein for ookinetes and sporozoites; CSP, circumsporozoite protein; PfEBA, Plasmodium falciparum erythrocyte binding antigen; PfRH, Plasmodium falciparum reticulocyte-binding homologue; PLP, perforin-like protein; PSPECT1, sporozoite protein essential for cell traversal 1; PvRBP, Plasmodium vivax reticulocyte-binding proteins; TRAP, thrombospondin-related adhesive protein. https://doi.org/10.1371/journal.ppat.1007943.g001 Traversal precedes invasion Sporozoites are deposited into the dermis of the host upon the bite of an infected mosquito. Plasmodium parasites contain fourteen 6-cysteine domains containing proteins, which are conserved among different Plasmodium species and play crucial role in fertilization, parasitophorous vacuole membrane fitness, and immune evasion 19. ...several members of this family are potential vaccine candidates 20. The receptor-binding pocket of PvDBP has limited polymorphisms in contrast to the other segments that are highly polymorphic 46. ...it is possible to develop therapeutics targeting the P. vivax DBP-DARC interface to reduce malaria. ...through advanced tools in genetics, structure biology, and immunoparasitology, we have gained immense knowledge about the Plasmodium invasion machinery and its individual components in the last few decades.