The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus

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The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus

Burgdorf, J; Zhang, X.-l; Weiss, C; Gross, A; Boikess, S.R; Kroes, R.A; Khan, M.A; Burch, R.M; Rex, C.S; Disterhoft, J.F; Stanton, P.K; Moskal, J.R

Neuroscience, 11/2015, Volume: 308

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Highlights • GLYX-13 produces antidepressant-like effects for ⩾1 week following a single dose. • GLYX-13 facilitates learning and memory for ⩾1 week following a single dose. • GLYX-13 enhances hippocampal metaplasticity 24 h – 2 weeks following a single dose. • Repeat doses of GLYX-13 maintained the metaplasticity effects for at least 8 weeks. • GLYX-13 increased the number of mature dendritic spines 24 h after a single dose.

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