PCR-electrophoresis analysis is an effective tool in the education of genetics and genome literacy, since variants of human genomic DNA can be visually observed as the profiles of the bands. It is a useful tool for the teaching of genetics and genome literacy in school. In the United States, variant analysis experimental kits and inexpensive, compact PCR devices are commercially available and used in schools. In the National Science Teachers Association (NSTA), electrophoresis often features in teacher training sessions for Science, Technology, Engineering, and Mathematics (STEM) education relating to understanding the human genome. The analysis of the experimenter’s own genomic DNA is effective in fostering literacy around genetics and the human genome. In Japan, experiments that handle genomes for educational purposes should also be carried out in accordance with official guidelines regarding dealing with personal genetic information, and appropriate methods of operation should be discussed and confirmed. In the future, it will be increasingly necessary to deepen our understanding of electrophoresis, experimental methods, the handling of personal genetic information, and the training of instructors in educational settings.