-
BDNF synthesis in cultures astrocytes is regulated by monoamines through the receptor mechanismLončar, Darja ...The focus of our present study was the regulatory effects of noradrenaline (NA) and serotonin (5-HT) on BDNF synthesis in astrocytes. Examined neurotransmitters potently increased BDNF content in ... cultured astrocytes in dose- and time-dependent manner: NA (1 miM; 6 h) by 4-fold and 5-HT (1 miM; 4 h) by 2.3-fold in cortical astrocytes and by 2.8- (1 miM; 6 h) and 1.7-fold (0.5 miM; 4 h) in cerebellar astrocytes. Phentolamine (alfa-adrenergic antagonist) showed no effect whereas sotalol (beta-adrenergic antagonist) dose-dependently inhibited the stimulatoty response on BDNF induced by NA, thereby supporting the conclusion that NA-stimulated BDNF synthesis in astrocytes is a beta-adrenergic receptor mediated process. Our results thus indicate the existence of a positive feed-back loop between the activity of monoaminergic neurons and astrocytic neurotrophic support.Vir: Glial cell function in health and disease [Elektronski vir] (Str. 109-112)Vrsta gradiva - prispevek na konferenciLeto - 2005Jezik - angleškiCOBISS.SI-ID - 20533721
Avtor
Lončar, Darja |
Miklič, Špela |
Jurič, Damijana Mojca |
Čarman-Kržan, Marija
Teme
Astrocytes |
Secretion |
Drug Effects |
Norepinephrine |
Serotonin |
Phentolamine |
Sotalol |
Rats |
Brain-Derived Neurotrophic Factor |
Cells, Cultured |
Astrociti |
Fentolamin |
Noradrenalin |
Serotonin |
Sotalol |
Celične kulture |
Možgani-izvirajoči, nevrotropni faktor |
Podgane
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Lončar, Darja | 24820 |
Miklič, Špela | 20344 |
Jurič, Damijana Mojca | 15169 |
Čarman-Kržan, Marija | 01169 |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.