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Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinaseCarey, Anrew L. ...Although interleukin-6 (IL-6) has been associated with insulin resistance, little is known regarding the effects of IL-6 on insulin sensitivity in humansin vivo. Here, we show that IL-6 infusion ... increases glucose disposal without affecting the complete suppression of endogenous glucose production during a hyperinsulinemic-euglycemic clamp in healthy humans. Because skeletalmuscle accounts for most of the insulin-stimulated glucose disposal invivo, we examined the mechanism(s) by which IL-6 may affect muscle metabolism using L6 myotubes. IL-6 treatment increased fatty acid oxidation, basal and insulin-stimulated glucose uptake, and translocation of GLUT4 to theplasma membrane. Furthermore, IL-6 rapidly and markedly increased AMP-activated protein kinase (AMPK). To determine whether the activation of AMPK mediated cellular metabolic events, we conducted experiments using L6 myotubes infected with dominant-negative AMPK alpha-subunit. The effects described above were abrogated in AMPK dominant-negative-infected cells. Our results demonstrate that acute IL-6 treatment enhances insulin-stimulated glucose disposal in humans in vivo, while the effects of IL-6 on glucose and fatty acid metabolism in vitro appear to be mediated by AMPK.Vir: Diabetes. - ISSN 0012-1797 (Letn. 55, št. 10, 2006, str. 2688-2697)Vrsta gradiva - članek, sestavni delLeto - 2006Jezik - angleškiCOBISS.SI-ID - 23594969
Avtor
Carey, Anrew L. |
Steinberg, Gregory R. |
Macaulay, Lance S. |
Thomas, Walter G. |
Holmes, Anna G. |
Ramm, Georg |
Prelovšek, Oja
Teme
Adult |
Aminoimidazole Carboxamide |
Analogs & Derivatives |
Pharmacology |
Animals |
Cell Line |
Cell Membrane |
Metabolism |
Fatty Acids |
Metabolism |
Glucose |
Metabolism |
Glucose Clamp Technique |
Hyperinsulinism |
Physiopathology |
Insulin |
Physiology |
Interleukin-6 |
Pharmacology |
Physiology |
Mice |
Mice, Knockout |
Multienzyme Complexes |
Metabolism |
Protein-Serine-Threonine Kinases |
Metabolism |
Rats |
Recombinant Proteins |
Pharmacology |
Ribonucleotides |
Pharmacology |
Signal Transduction |
Drug Effects |
Aminoimidazolov karboksamid |
Beljakovina-serin-treoninska kinaza |
Celična linija |
Celična membrana |
Glukoza |
Glukoza, zajetje, tehnika |
Hiperinzulinizem |
Interlevkin-6 |
Inzulin |
Maščobne kisline |
Miši |
Miši Knockout |
Multiencimski kompleksi |
Odrasli |
Podgane |
Rekombinantne beljakovine |
Ribonukleotidi |
Signal, prevajanje |
Živali
Vnos na polico
Trajna povezava
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Faktor vpliva
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Baze podatkov, v katerih je revija indeksirana
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Carey, Anrew L. | |
Steinberg, Gregory R. | |
Macaulay, Lance S. | |
Thomas, Walter G. | |
Holmes, Anna G. | |
Ramm, Georg | |
Prelovšek, Oja | 24281 |
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