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Screening for Down's syndrome and neural tube defect in Croatia : a regional prospective studyBrajenović-Milić, Bojana ...Objective: The purpose of this study was to investigate the efficiency of second-trimester maternal serum screening for Down's syndrome and open neural tube defects using alpha-fetoprotein and free ... beta-human chorionic gonadotropin as serum markers. Methods: 3, 188 women underwent testing between14th and 22nd week of pregnancy. Of all tested patients, 25.4% were >/=35 years old. A cut-off risk of >/=1:250 for Down's syndrome and MS-AFP >/=2.0 MoM for open neural tube defect were considered screen-positive. Results: The detection rate for Down's syndrome was 77.8% (7/9) with 8.2% screen-positive rate (7.9% false-positive rate). When evaluated separately, inpatients younger than 35 and in those >/=35 years old, the screen-positive rates were 3.1 and 23.3%, respectively. A total of 52 (1.6%) were found screen-positive for open neural tube defect; 2 cases of encephalocela and 1 case of gastroschisis were confirmed prenatally. Conclusion: The respectable number of cases with trisomy 21 identified in this study confirms that routinemid-trimester screening for Down's syndrome including MS-AFP, free beta-hCG and maternal age is useful in identifying pregnancies at increased risk.Vir: Fetal diagnosis and therapy. - ISSN 1015-3837 (Letn. 13, št. 6, 1998, str. 367-371)Vrsta gradiva - članek, sestavni delLeto - 1998Jezik - angleškiCOBISS.SI-ID - 26880985
Avtor
Brajenović-Milić, Bojana |
Tišlarić, Dubravka |
Bačić, Josip, medicina |
Paravić, Jadranka |
Slivar, Anatelo |
Kapović, Miljenko |
Košec, Vesna |
Ristić, Smiljana |
Rajhvajn, Branko
Teme
Prenatal Diagnosis |
Adult |
Amniocentesis |
Chorionic Gonadotropin, Beta Subunit, Human |
Blood |
Croatia |
Down Syndrome |
Diagnosis |
False Positive Reactions |
Fetal Diseases |
Diagnosis |
Gestational Age |
Karyotyping |
Maternal Age |
Neural Tube Defects |
Diagnosis |
Pregnancy |
Prospective Studies |
Alpha-Fetoproteins |
Analysis |
Predrojstvena diagnostika |
Prospektivne študije |
Živčna cev, anomalije |
Amniocenteza |
Odrasli |
Lažno pozitivne reakcije |
Kariotip, določanje |
Alfa-fetoproteini |
Horionski gonadotropin, beta podenota, človeka |
Hrvaška |
Downov sindrom |
Gestacijska starost |
Nosečnost |
Plod, bolezni |
Porodnice, starost
Vnos na polico
Trajna povezava
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Faktor vpliva
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Brajenović-Milić, Bojana | |
Tišlarić, Dubravka | |
Bačić, Josip, medicina | |
Paravić, Jadranka | |
Slivar, Anatelo | |
Kapović, Miljenko | 32606 |
Košec, Vesna | |
Ristić, Smiljana | |
Rajhvajn, Branko |
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