-
The association between brain-derived neurotrophic factor polymorphism (BDNF Val66Met) and suicidePregelj, Peter ...Background: Brain-derived neurotrophic factor (BDNF) mediates neural plasticity, mood, different behaviours, and stress response. A functional BDNFpolymorphism (BDNF Val66Met) was reported to ... influence the effects of stressful life events or childhood adversity on depression and suicidal behaviour in various psychopathologies. The study evaluated the association between BDNF Val66Met variants and suicide, committed with violent or non- violent methods, in victims with or without stressful childhood experience. Methods: BDNF Val66Met polymorphism was genotyped on 560 DNA samples from 359 suicide victims and 201 control subjects collected on autopsy from unrelated Caucasian subjects and subdivided according to gender, method of suicide, and influence of childhood adversity. Results: A similar frequency of BDNF Val66Met variants was found between all included suicide victims and the control groups, and also between the male groups. The frequency of the combined Met/Met and Met/Val genotypes and the homozygous Val/Val genotype wassignificantly different between the female suicide victims and female controls, between the female suicide victims who used violent suicide methods and female controls, and between all included suicide victims with or without stressful life events. The combined Met/Met and Met/ Val genotypes contributedto this significance. Limitation: A small group of suicide victims with available data on childhood adversity was studied. Conclusions: The combined Met/Met and Met/Val genotypes of the BDNF Val/Met variant could be the risk factor for violent suicide in female subjects and for suicide in victims exposed to childhood trauma. These results confirm a major role of BDNF in increased vulnerability to suicide.Vir: Journal of affective disorders. - ISSN 0165-0327 (Vol. 128, issue 3, 2011, str. 287-290)Vrsta gradiva - članek, sestavni delLeto - 2011Jezik - angleškiCOBISS.SI-ID - 27184089
Avtor
Pregelj, Peter |
Nedić, Gordana |
Videtič Paska, Alja, 1980- |
Zupanc, Tomaž |
Nikolac, Matea |
Balažic, Jože, 1954- |
Tomori, Martina |
Komel, Radovan |
Muck Seler, Dorotea |
Pivac, Nela
Teme
Suicide |
Brain-Derived Neurotrophic Factor |
Neuronal Plasticity |
Polymorphism (Genetics) |
Stress, Psychological |
Autopsy |
Samomor |
Možgani-izvirajoči, nevrotropni faktor |
Polimorfizem (genetika) |
Nevronska plastičnost |
Stres psihološki |
Obdukcija
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Pregelj, Peter | 18323 |
Nedić, Gordana | ![]() |
Videtič Paska, Alja, 1980- | 27742 |
Zupanc, Tomaž | 22072 |
Nikolac, Matea | ![]() |
Balažic, Jože, 1954- | 05353 |
Tomori, Martina | 02703 |
Komel, Radovan | 06135 |
Muck Seler, Dorotea | ![]() |
Pivac, Nela | ![]() |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.