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Novel estrogen-related genes and potential biomarkers of ovarian endometriosis identified by differential expression analysisVouk, Katja ...In the search for novel biomarkers of endometriosis, we selected 152 genes from the GeneLogic database based on results of genome-wide expression analysis of ovarian endometriosis, plus 20 genes ... related to estrogen metabolism and action. We then performed low-density array analysis of these 172 genes on 11 ovarian endometriosis samples and 9 control endometrium samples. Principal component analysis of the gene expression levels showed clear separation between the endometriosis and control groups. We identified 78 genes as differentially expressed. Based on Ingenuity pathway analysis, these differentially expressed genes were arranged into groups according to biological function. These analyses revealed that 32 differentially expressedgenes are estrogen related, 23 of which have not been reported previously in connection with endometriosis. Functional annotation showed that25 and 22 genes are associated with the biological terms "secreted" and "extracellular region", respectively. Differential expression of 4 out of 5 genes related to estrogen metabolism and action (ESR1, ESR2, PGR and BGN) was also confirmed by immunohistochemistry. Our study thus reveals differential expression of several genes that have not previously been associated with endometriosis and that encode potential novel biomarkers and drug targets.Vir: Journal of Steroid Biochemistry and Molecular Biology. - ISSN 0960-0760 (Vol. 125, issue 3/5, 2011, str. 231-242)Vrsta gradiva - članek, sestavni delLeto - 2011Jezik - angleškiCOBISS.SI-ID - 28170457
Avtor
Vouk, Katja |
Šmuc, Tina, 1980- |
Guggenberger, Christina |
Ribič-Pucelj, Martina |
Šinkovec, Jasna, 1944- |
Lanišnik-Rižner, Tea
Teme
Ovarian Diseases |
Endometriosis |
Diagnosis |
Genetics |
Estrogens |
Metabolism |
Gene Expression |
Genetic Markers |
Immunohistochemistry |
Polymerase Chain Reaction |
Gensko izražanje |
Endometrioza |
Jajčnik, bolezni |
Estrogeni |
Genetski označevalci |
Polimerazna, verižna reakcija |
Imunohistokemija
Vnos na polico
Trajna povezava
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Faktor vpliva
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vouk, Katja | 16114 |
Šmuc, Tina, 1980- | 25593 |
Guggenberger, Christina | |
Ribič-Pucelj, Martina | 05274 |
Šinkovec, Jasna, 1944- | 07183 |
Lanišnik-Rižner, Tea | 11699 |
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