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Tumour necrosis factor-alpha inhibitor-induced hepatic injury in patients withrheumatoid arthritis : two case reports and an analysis of the laboratory data from the Slovenian national biologicals registryPerdan-Pirkmajer, Katja ...Tumour necrosis factor-alpha (TNF-alpha) inhibitors are widely used in the management of patients with rheumatoid arthritis (RA) and spondylarthritides. However, TNF-alpha inhibition may lead to ... adverse events, including liver injury. The RA patients are frequently treated with several potentially hepatotoxic drugs concomitantly; hence, a causative link between TNF-alpha inhibitors and liver injury is usually difficult to establish. We report two cases of RA patients who developed histologically manifest liver injury shortly after the introduction of treatment with two different TNF-alpha inhibitors. Furthermore, we present the analysis of the laboratory data from the BioRx.si registry (the Slovenian national registry of rheumatologic patients treated with biologicals) and provide evidence that elevated levels of serum aminotransferase can be observed in patients treated with TNF-alpha inhibitors. Additionally, our analysis suggests no significant differences between the impact of adalimumab and etanercept on aminotransferase levels. Although the use of TNF-alpha inhibitors is safe and efficient, we suggest that continuous careful monitoring of aminotransferase levels in patients treated with these agents is probably warranted.Vir: Rheumatology international. - ISSN 0172-8172 (Vol. 33, iss. 11, Nov. 2013, str. 2885-2888)Vrsta gradiva - članek, sestavni delLeto - 2013Jezik - angleškiCOBISS.SI-ID - 30176985
Avtor
Perdan-Pirkmajer, Katja |
Hočevar, Alojzija |
Rotar, Žiga |
Ferlan-Marolt, Vera |
Žibert, Janez, 1974- |
Gučev, Filip |
Tomšič, Matija, 1959-
Teme
Arthritis, Rheumatoid |
Drug Therapy |
Tumor Necrosis Factor |
Antagonists And Inhibitors |
Toxicity |
Liver |
Drug Effects |
Alanine Aminotransferase |
Blood |
Aspartate Aminotransferase |
Blood |
Adult |
Artritis revmatični |
Tumor nekrotizirajoči faktor |
Jetra |
Odrasli
Vnos na polico
Trajna povezava
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Faktor vpliva
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Perdan-Pirkmajer, Katja | 29467 |
Hočevar, Alojzija | 22344 |
Rotar, Žiga | 30545 |
Ferlan-Marolt, Vera | 07192 |
Žibert, Janez, 1974- | 19236 |
Gučev, Filip | |
Tomšič, Matija, 1959- | 13601 |
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