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  • Association of thioredoxin reductase 2 (TXNRD2) gene polymorphisms with myocardial infarction in Slovene patients with type 2 diabetes mellitus
    Kariž, Stojan ; Mankoč Ramuš, Sara ; Petrovič, Danijel, 1963-
    Objectives: The aim of our study was to investigate the relationship between genetic polymorphisms in the mitochondrial thioredoxin reductase 2 (TrxR2) and myocardial infarction (MI) in subjects with ... type 2 diabetes mellitus (T2DM) of Slovenian origin. Methods: The study population consisted of 972 Caucasian subjects with T2DM of more than 10 years' duration: 161 patients with MI and 811 patients with no history of coronary artery disease. Polymorphisms in thioredoxin reductase 2 (TXNRD2) gene, rs1548357, rs4485648, and rs5748469, were studied. Results: Individuals carrying CC + CT genotypes of rs1548357 TXNRD2 polymorphism had lower prevalence of MI compared with TT genotype group (41.6% vs 52.8%, OR=0.589, 95% CI=0.368%0.942, P = 0.027). Conclusions: The TXNRD2 rs 1548357 polymorphism might be a genetic risk factor for MI in subjects with T2DM of Slovenian origin.
    Vir: Diabetes research and clinical practice. - ISSN 0168-8227 (Vol. 108, iss. 2, May 2015, str. 323-328)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2015
    Jezik - angleški
    COBISS.SI-ID - 31868633

    Povezava(-e):

    http://www.sciencedirect.com/science/article/pii/S0168822715000789
    DOI

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