-
Endocrine activities and adipogenic effects of bisphenol AF and its main metaboliteGramec, Darja, farmacevtka ...Bisphenol AF (BPAF) is a fluorinated analog of bisphenol A (BPA), and it is a more potent estrogen receptor (ER) agonist. BPAF is mainly metabolized to BPAF-glucuronide (BPAF-G), which has been ... reported to lack ER agonist activity and is believed to be biologically inactive. The main goal of the current study was to examine the influence of the metabolism of BPAF via glucuronidation on its ER activity and adipogenesis. Also, as metabolites can have different biological activities, the effects of BPAF-G on other nuclear receptors were evaluated. First, in-vitro BPAF glucuronidation was investigated using recombinant human enzymes. Specific reporter-gene assays were used to determine BPAF and BPAF-G effects on estrogen, androgen, glucocorticoid, and thyroid receptor pathways, and on PXR, FXR, and PPAR[gamma] pathways. Their effects on lipid accumulation and differentiation were determined in murine 3T3L1 preadipocytes using Nile Red, with mRNA expression analysis of the adipogenic markers adiponectin, Fabp4, Ceb[alpha], and PPAR[gamma]. BPAF showed strong agonistic activity for hER[alpha] and moderate antagonistic activities for androgen and thyroid receptors, and for PXR. BPAF-G was antagonistic for PXR and PPAR[gamma]. BPAF (0.1%microM) and BPAF-G (1.0%microM) induced lipid accumulation and increased expression of key adipogenic markers in murine preadipocytes. BPAF-G is therefore not an inactive metabolite of BPAF. Further toxicological and epidemiological investigations of BPAF effects on human health are warranted, to provide better understanding of the metabolic end-elimination of BPAF.Vir: Chemosphere. - ISSN 0045-6535 (Vol. 215, Jan. 2019, str. 870-880)Vrsta gradiva - članek, sestavni delLeto - 2019Jezik - angleškiCOBISS.SI-ID - 4620401
Avtor
Gramec, Darja, farmacevtka |
Carino, Adriana |
Trontelj, Jurij |
Troberg, Johanna |
Distrutti, Eleonora |
Marchianò, Silvia |
Tomašič, Tihomir |
Zega, Anamarija |
Finel, Moshe |
Fiorucci, Stefano |
Peterlin-Mašič, Lucija
Teme
Farmacevtska kemija |
bisphenol AF |
bisphenol AF glucuronide |
glucuronidation endocrine activities |
lipid accumulation
Avtor | Gramec, Darja, farmacevtka ... |
Naslov | Endocrine activities and adipogenic effects of bisphenol AF and its main metabolite |
Datum objave | 2019-01-29 |
COBISS.SI-ID | 4620401 |
Verzija objave v repozitoriju | Založnikova različica |
Licenca objave v repozitoriju | Creative Commons Priznanje avtorstva 4.0 Mednarodna |
Embargo | Takojšnja javna objava |
Projekti, iz katerih je bila financirana objava
Naziv | Akronim | Številka projekta | Financer |
---|---|---|---|
Farmacevtska kemija: načrtovanje, sinteza in vrednotenje učinkovin | P1-0208-2015 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
Datoteke, ki spadajo k objavi
Povezava |
---|
https://www.sciencedirect.com/science/article/pii/S0045653518319908#! |
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Gramec, Darja, farmacevtka | 35432 |
Carino, Adriana | |
Trontelj, Jurij | 23420 |
Troberg, Johanna | |
Distrutti, Eleonora | |
Marchianò, Silvia | |
Tomašič, Tihomir | 28334 |
Zega, Anamarija | 18633 |
Finel, Moshe | |
Fiorucci, Stefano | |
Peterlin-Mašič, Lucija | 19317 |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.