-
Effect of solution composition variables on electrospun alginate nanofibers [Elektronski vir] : response surface analysisMirtič, Janja, farmacevtka ...Alginate is a promising biocompatible and biodegradable polymer for production of nanofibers for drug delivery and tissue engineering. However, alginate is difficult to electrospin due to its ... polyelectrolyte nature. The aim was to improve the 'electrospinability' of alginate with addition of exceptionally high molecular weight poly(ethylene oxide) (PEO) as a co-polymer. The compositions of the polymer-blend solutions for electrospinning were varied for PEO molecular weight, total (alginate plus PEO) polymer concentration, and PEO proportion in the dry alginate PEO polymer mix used. These were tested for rheology (viscosity, complex viscosity, storage and loss moduli) and conductivity, and the electrospun nanofibers were characterized by scanning electron microscopy. One-parameter-at-a-time approach and response surface methodology (RSM) were used to optimize the polymer-blend solution composition to obtain defined nanofibers. Both approaches revealed that the major influence on nanofiber formation and diameter were total polymer concentration and PEO proportion. These polymer-blend solutions of appropriate conductivity and viscosity enabled fine-tuning of nanofiber diameter. PEO molecular weight of 2-4 million Da greatly improved the electrospinnability of alginate, producing nanofibers with >85% alginate. This study shows that RSM can be used to design nanofibers with optimal alginate and co-polymer contents to provide efficient scaffold material for regenerative medicine.Vir: Polymers [Elektronski vir]. - ISSN 2073-4360 (Vol. 11, iss. 4, Apr. 2019, str. 1-20)Vrsta gradiva - e-članekLeto - 2019Jezik - angleškiCOBISS.SI-ID - 4704625
Avtor
Mirtič, Janja, farmacevtka |
Balažic, Helena, farmacevtka |
Zupančič, Špela, farmacevtka |
Kristl, Julijana
Teme
Nanomateriali |
nanovlakna |
elektrospiniranje |
alginat |
polietilen oksid |
prevodnost |
viskoelastične lastnosti |
metodologija odzivne površine |
nanofibers |
electrospinning |
alginate |
polyethylene oxide |
conductivity |
viscoelastic properties |
response surface methodology
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Mirtič, Janja, farmacevtka | 39199 |
Balažic, Helena, farmacevtka | |
Zupančič, Špela, farmacevtka | 36439 |
Kristl, Julijana | 09032 |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.