-
Deformation properties of pharmaceutical excipients determined using an in-dieand out-die methodIlić, Ilija ...This study investigated deformation mechanisms of some commonly used pharmaceutical fillers, such as microcrystalline cellulose, lactose, dicalcium phosphate, isomalt and cornstarch, using a ... combination of the in-die and out-die method with the Heckel and Walker models. The tableting mixtures contained of 98.5% (w/w) filler, the rest consisted of dry binder and an anti adhesive agent. Our results showed that plasticity and elasticity may be considered independent deformation properties as highly plastic materials (microcrystalline cellulose, cornstarch) also exhibited high elasticity. Particular emphasis was placed on explaining the differences observed between the in-die and out-die methodŽcomparison revealed that the differences are a consequence of the material's elastic properties. Larger error of in-die results can be expected for more elastic materials, and thus in-die Heckel should be used with some considerations. In contrast, the Walker model was found to be more robust and smaller differences were observed between the two methods. We consider the most correct results to have been obtained by the out-die approach, which excludes the elastic properties of the material evaluated. An excellent correlation between elastic determination at the single-particle level and multiple-particle scale was demonstrated, suggesting a great potential of nanoscale determination of a material's mechanical properties for better elucidation of deformation mechanisms.Vir: International journal of pharmaceutics. - ISSN 0378-5173 (Vol. 446, issue 1/2, 2013, str. 6-15)Vrsta gradiva - članek, sestavni delLeto - 2013Jezik - angleškiCOBISS.SI-ID - 3407985
Povezava(-e):
http://www.sciencedirect.com/science/article/pii/S037851731300135XDostop možen preko konzorcija Univerze v Ljubljani
Avtor
Ilić, Ilija |
Janković, Biljana, 1982- |
Šibanc, Rok |
Dreu, Rok |
Srčič, Stanko
Teme
Heckell |
Walker |
in-die |
out-die |
nanoindentation |
deformation |
trdne farmacevtske oblike |
dostavni sistemi |
tablete |
pomožne snovi |
Hecklov model |
Walker model
![loading ... loading ...](themes/default/img/ajax-loading.gif)
vir: International journal of pharmaceutics. - ISSN 0378-5173 (Vol. 446, issue 1/2, 2013, str. 6-15)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Ilić, Ilija | 28446 |
Janković, Biljana, 1982- | 34670 |
Šibanc, Rok | 29888 |
Dreu, Rok | 21455 |
Srčič, Stanko | 09031 |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.