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  • Pomen sledenja srčne funkcije pri mladostnikih, zdravljenih z antraciklini zaradi raka v otroštvu = Importance of follow up of cardiac function after treatment with anthracyclines for cancer in childhood
    Velenšek Prestor, Veronika ...
    Background. In a a retrospecrive study the influence of antracyclines therapy and of the risk factors was analysed. The aim of our study was further to define the most sutiable method for detection ... late cardiac toxicity caused by antracyclines. Methods. Fourty-sixpatients, 2-17years old at diagnosis were included. The time of follow up was 5-23 years. Thirty-four patients received a cumulative dosis of antracycline (AC) between 50 and 540 mg/m2 (mean 203 mg/m2) and I2 were not treated with AC (control group). The methods of evaluation of cardiac performance included: clinical history, physical examination, electrocardiogram (ECG), ECG exercise testing on a bicycle ergometer and echocardiography. For statistical analysis the Chi2 test and theT test were used. Results. Exercise tolerance was below the predicted values in 23 (50%) of all patients. In 21 (46%) patients ECG abnormalities were found. Treatment with AC influenced the ECG exercise testing. Seven patients (19%) had mitral insufficiency; the concomitant treatment with AC andalkylating agents correlated with mitral insufficiency. The concomitant treatmenth with AC and alkylating agens was also correlated with prolonged isovolumic relaxation time (IVRT) and influenced significantly the volume of the left atrium (p = 0.02). Sixteen ( 52%) survivors had IVRT 90 = ms. There were no significant diferences in other parameters of diastolic or systolic function. Conclusions. In survivors treated with anthracyclines abnormalities of the cardiac function are more frequent than in those who had no anthracycline therapy, mainly manifested as abnormal diastolic function. Closefollow up of survivors of anthracyclines therapy is necessary; it allows identification of subclinical carditoxicity.
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 69, št. 7/8, jul.-avg. 2000, str. 499-504)
    Vrsta gradiva - članek, sestavni del
    Leto - 2000
    Jezik - slovenski
    COBISS.SI-ID - 11831769

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