Defense mechanisms in Listeriosis : a model for cell-mediated immunity = Obrambni mehanizmi pri listeriozi : model celično posredovane imunosti
Hof, Herbert
Among the various species of the genus Listeria only L. monocytogenes is regarded as facultative pathogenic; there is a broad spectrum of animals whichare susceptible to these bacteria thus the mouse ...serves as a model for studying the pathophysiology of this infection. The multiplication in the mouse takes place primarily in the spleen and liver. Thereby, the bacteria multiply within host cells. Listeriae are unique in their behaviour to leave the phagocytic vacuole and to penetrate into the cytosol of the host cell. In principle they are able to spread from cell to cell so that there is no extracellular stage necessary. This means that humoral defense mechanisms are of minor importance. At the beginning of infection non-specific defense is mediated by polymorphonuclear granulocytes. This may help to slow down the multiplication rate, but curing is only achieved when a T cell-mediated immuneresponse takes place, Nude, athymic mice devoid of T-lymphocyces are unable to mount any imunity. Certain bacterial epitopes which are processed intracellulary in the host cell are presented at the surface of the host cell in the context of MHC class I or class II molecules. The antigenic epitopes presented by MHC class I are recognized by CD8+T cells, whereas epitopes on MHC class II are presented to CD4+T cells. Both types of T-lymphocytes are involved in protection against L. monocytogenes. By this strong immune reaction the bacterial infection is abrogated after a few days; this immunity will persist for months but gradually declines with time.
Bibliografsko gradivo je bilo uspešno dodano na polico.
Dodajanje bibliografskega gradiva na polico ni uspelo.
Gradivo je že na polici.
Trajna povezava
URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto
Faktor vpliva
Izdaja
Kategorija
Razvrstitev
JCR
SNIP
JCR
SNIP
JCR
SNIP
JCR
SNIP
Izberite knjižnično izkaznico:
Baze podatkov,
v katerih je revija indeksirana
Ime baze podatkov
Področje
Leto
Povezave do osebnih bibliografij avtorjev
Povezave do podatkov o raziskovalcih v sistemu SICRIS
Storitev za pridobivanje naslova trenutno ni dostopna, prosimo, poskusite še enkrat.
S klikom na gumb "V redu" boste potrdili zgoraj izbrano prevzemno mesto in dokončali postopek rezervacije.
S klikom na gumb "V redu" boste potrdili zgoraj izbrano prevzemno mesto in naslov za dostavo ter dokončali postopek rezervacije.
S klikom na gumb "V redu" boste potrdili zgoraj izbrani naslov za dostavo in dokončali postopek rezervacije.
Obvestilo
Trenutno je storitev za avtomatsko prijavo in rezervacijo nedostopna. Gradivo lahko rezervirate sami na portalu Biblos ali ponovno poskusite tukaj kasneje.
Citiranje
Funkcionalnost trenutno ni na voljo. Prosimo, poskusite kasneje.
Naročanje gradiva za izposojo v čitalnice
Naročanje kopij člankov
Urnik dostave gradiva z oznako DS v signaturi