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  • Opredelitev akutnih limfoblastnih levkemij s celičnimi imunološkimi označevalci = Immunological classification of acute lymphoblastic leukemias
    Zver, Samo, 1966- ; Modic, Mojca, 1954- ; Žontar, Darja
    Background. ALL is a malignant blood disease and lymphoblasts have origin in Bor T lymphatic cell line. In 1997 established new World Health Organisation classification (WHO classification) of ... malignant heamatological diseases realizes the importance of cellular immunological markers (immunophenotype) and chromosomal abnormalities (cytogenetics). Based on both findings we may distribute the patients in low, intermediate and high risk groups and the outcome of such distribution is risk adopted ALL treatment strategy. On Clinical department of haematology (CDH) we have decided to overview immunophenotype characteristics of all ALL patients during the January 1, 1995-December 31, 2001 period. Methods and results. During the January 1, 1995-December 31, 2001 period on CDH we have treated 44 patients: 22 males and22 females. With flow cytometer Coulter Epics XL MCS we have performed first primary antibody panel for acute leukemias antigens (CD2, CD7, CD10, CD19, CD34, cCD3, cCD13, cCD22, MPO, TdT), followed by secondary panel. The later have included antigen CD20, CD23, membrane and/or cytoplasmatic immunoglobulins or their light chains monoclonal antibodies for B-ALL and antigen CD3, CD4, CD5 and CD8 monoclonal antibodies for T-ALL subsets. Besidesimmunophenotyping we have evaluated all ALL patients also morphologically according to FAB classification (French-American-British classification), which is an old classification based solely on morphology. 32/44 (73%) patients have had immunophenotypic B-ALL, and 12/44 (27%) T-ALL. Subgroups distribution of B-ALL immunophenotype were: pro-B 4/44 (9%), "common"-B 18/44 (41%), pre-B 5/44 (11.5%) and mature B 5744 (11.5%) and for T-ALL imunophenotype were: pro-T 2/44 (4.5%), pre-T 5/44 (11.5%), cortical-T 4/44 (9%) and mature-T 1/44 (2%). (Abstract truncated at 2000 characters).
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 71, št. 5, maj 2002, str. 303-306)
    Vrsta gradiva - članek, sestavni del
    Leto - 2002
    Jezik - slovenski
    COBISS.SI-ID - 14876121

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    Digitalna knjižnica Slovenije - dLib.si

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