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  • Epithelial hyperplastic lesion in chronic hyperplastic laryngitis of patients treated from 1994 to 1998 at the Department of otorinolaryngology and cervicofacial surgery in Ljubljana = Hiperplastične spremembe epitela pri bolnikih s kroničnim laringitisom, zdravljenih od 1994-1998 na Kliniki za otorinolaringologijo in cervikalno kirurgijo v Ljubljani
    Fischinger, Janez
    Different grades of epithelial hyperplastic lesions can be found in various pathological entities, e.g. chronic laryngitis, polyps, nodules, Renike's edema, papillomas, and cysts. Among all these ... entities, atypical hypeplasia orrisky epithelium occurs most frequently in chronic hyperplastic laryngitis. Malignant transformation develops almost exclusively in this type of aberration. The aim of this study was to determine the main ethiologic agents and to evaluate the frequency of histomorphologic epithelial changes, the male-female ratio, age and sex distribution of patients with a diagnosis of chronic laryngitis from the Ljubljana region treated in the period from 1994 to 1998 at the Department Otorhinolaryngology and Cervicofacial Surgery, Clinical Centre, Ljubljana. A retrospective clinical pathological analysis wasperformed on a series of 178 patients with 239 biopsies. The laryngeal biopsies were classified according to the Ljubljana classification. According to the degree of epithelial lesions, a histologic diagnosis of atypical hyperplasia (risky epithelium) was established in 8.1% of cases. The patients ages ranged from 21 to 89 years. The highest frequency of chronic laryngitis was in females between 40 and 49, and in male patients between 50 and 59 years. The male-female ratio was 8:1. We found that 79% of patients diagnosed with chronic laryngitis were smokers and 31% alcoholics. Nearly half (48%) of patients were employed in industry. There is a need for long term follow-up observation to obtain a reliable percentage of malignant transformations in atypical hyperplasia in our series. Cognition that atypical hyperplasia may transform into cancer requires that increasing attention is paid to early detection and adequate treatment.
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 71, supl. 3, nov. 2002, str. III-69-III-71)
    Vrsta gradiva - članek, sestavni del
    Leto - 2002
    Jezik - angleški
    COBISS.SI-ID - 15697625

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