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Učinki elektrogenske terapije s p53wt v kombinaciji s cisplatinom na preživetje človeških tumorskih celičnih linij = Effects of electrogene therapy with p53wt combined with cisplatin on survival of human tumor cell linesČemažar, Maja ...The aim of this study was to evaluate electrogenetherapy with p53wt alone or combined with cisplatin in two colorectal (HT29 and LoVo) and two prostatic (PC3 and Du145) carcinoma cell lines with ... different p53 statuses. Electrogenetherapy with p53wt was dependent on the p53 status of the cell lines used. Electrogenetherapy was the most effective in PC-3 (p53 null) and Du145 (p53mt) cells and to a much lesser extent in LoVo cells (p53wt). An exception was the HT-29 cell line with an overexpressed mutated p53, in which electrogenetherapy with p53wt was the least effective. Sensitivity of the celllines to cisplatin was independent of the p53 status. Furthermore, the presence of exogenous p53 due to electrogenetherapy did not enhance cisplatin cytotoxicity, since the combination of these therapies resulted in an additivecytotoxic effect.Vir: Medicinski razgledi. Supplement. - ISSN 0353-3484 (Letn. 43, supl. 5, okt. 2004, str. 153-158)Vrsta gradiva - prispevek na konferenciLeto - 2004Jezik - slovenskiCOBISS.SI-ID - 18602201
Avtor
Čemažar, Maja |
Grošel, Alenka |
Kranjc Brezar, Simona |
Škoberne, Mojca, 1972- |
Kotnik, Vladimir |
Serša, Gregor
Teme
Tumor Cells, Cultured |
Drug Effects |
Gene Therapy |
Electroporation |
Cell Survival |
Neoplasms |
Immunology |
Therapy |
Celica, preživetje |
Elektroporacija |
Gensko zdravljenje |
Tumorske celične kulture |
Novotvorbe |
tumorske celice |
gensko zdravljenje |
biokemija |
elektroporacija
Vnos na polico
Trajna povezava
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Čemažar, Maja | 14575 |
Grošel, Alenka | 21329 |
Kranjc Brezar, Simona | 19058 |
Škoberne, Mojca, 1972- | 18356 |
Kotnik, Vladimir | 07756 |
Serša, Gregor | 08800 |
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